Thus, the atherosclerosis caused by high insulin resistance levels may affect the ALPS index and influence the glymphatic system's activity because of the deterioration of the arterial pulsation that contributes to the driving force of CSF in the glymphatic system, thereby causing impairment glymphatic system functionality (Jessen et al., 2015; Li et al., 2021). This evidence concerns the gene INS and atherosclerosis.