All suboptimal adherents discussed the psychosocial disadvantages relevant to diabetes care, including negative emotional reactions such as anxiety, depression, among others; ideals for weight; intolerance of regularity; fear of needles and testing, fear of hypoglycemia, which resulted in omitting insulin to avoid hypoglycemia; feeling the burden of counting CHO in their meals and synchronizing insulin dose with CHO content (Quotes # 33). The gene discussed is INS; the disease is major depressive disorder.