At the same time, studies have also shown that SUA could interfere with the insulin signaling pathway at the receptor level through ENPP1 (hexanucleotide pyrophosphatase/phosphodiesterase 1) recruitment, affect glucose homeostasis, and change the level of HbA1c in the body, indicating that hyperuricemia will promote the occurrence of new diabetes [24]. Here, ENPP1 is linked to diabetes mellitus.