Interestingly, a genome-wide study found an association between low-grade fat accumulation and rs10859525 and rs1294908, which are located upstream of SOCS2 and RAMP3, respectively, suggesting that SOCS2 and RAMP3 may serve as predictors of NAFLD disease progression (Di Stefano et al., 2015). The gene discussed is SOCS2; the disease is metabolic dysfunction-associated steatotic liver disease.