GSK3B and cancer: Besides, anti-ENO1 mAb could attenuate lung cancer cell proliferation, invasion, and metastasis by inhibiting ENO1-mediated GSK3β activation and inactivating the Wnt pathway (Li et al., 2021), and MET might restrain the survival of cancer cells, the stemness of CSCs and EMT by inactivating the Wnt/β-catenin pathway (Conza et al., 2021; Zhang & Wang, 2019).