Since CAV1 mRNA and protein overexpression can induce EMT marker overexpression in various cancer cell lines,37, 38, 39, 40, 41 CAV1, that participates to caveolar endocytosis,7, 8 could be intermediate between PROM2 and EMT markers in our in vitro and in vivo melanoma models. This evidence concerns the gene PROM2 and melanoma.