For example, PRAME, which is a membrane protein highly expressed by human metastatic melanomas,49 could be used to engineer an antibody‐drug conjugate with an anti‐PROM2 ASO; (iii) their penetration into the cancer cell, requiring specific engineering of an ASO capable of gymnotic diffusion into the cell, as we achieved here. The gene discussed is PRAME; the disease is metastatic melanoma.