We chose an ASO approach for several reasons: (i) PROM2 protein expression is correlated with mRNA expression in our melanoma models; (ii) PROM2 protein overexpression is associated with the metastatic process during cell detachment and migration and is largely part of the membrane of multivesicular bodies to expulse Fe2+ in exosomes out of cancer cells to promote ferroptosis resistance,9, 47 (iii) finally PROM2 is a pentaspan protein and data are lacking on functional domains, making it difficult to engineer an appropriate therapeutic monoclonal antibody. Here, PROM2 is linked to melanoma.