We found that the expression levels of crucial molecules in the IL-17 signaling pathway, including IL-17A, IL-6, and IL-23, were significantly enhanced in the heat-killed P. intermedia group compared with the control group (Fig. 7d), while the expression levels of tumor suppressors, including GABBR2 (Fig. 8j), FASL and P63 (Fig. 9c), in the heat-killed P. intermedia groups were significantly lower than those in the control group. Here, IL6 is linked to neoplasm.