The MIF signals sent by glioma cells (Clusters C1, C2 and C4) were mainly received by TAMs (Cluster C0) via receptors CD74 and CXCR4, and by lymphocytes (Cluster C6) via CD74, CXCR4 and CD44 (Fig. 1e, f). Here, CXCR4 is linked to glioma.