On the other hand, TAM-AIF1, characterized by the high expression of C1QB, C1QA, HLA-DRB1, is likely a type of glioma-specific tissue-resident microglia suggested by their high expression of microglia markers such as P2RY12, TMEM119. In support of this, a group of tissue resident macrophage (C1Q+macrophages) has been reported to express similar marker genes (C1q, HLA-DR) in several other tumor types. Here, C1QA is linked to central nervous system cancer.