However, in both TCGA and CBCS, BIRC5-high tumors were more common among Luminal B (LumB), Her2-enriched, Basal-like, ROR-PT-high and ER-negative tumor subtypes, as well as higher-stage tumors, and were more frequent among cases from Black women and younger women (< 50 years of age). Here, ESR1 is linked to neoplasm.