MTHFD1 and MTHFD2, but not SSP genes or SHMT1/2, were significantly associated with worse overall survival in LUAD patients from the TCGA cohort (Fig. 1C, Supplementary Figure S1), MTHFD1, the cytoplasmic isoform, was even an independent prognostic factor in LUAD patients in multivariate survival analysis including also the tumor stage (Table 1). The gene discussed is SHMT1; the disease is neoplasm.