In the TCGA datasets of the two main subtypes of NSCLC, adenocarcinoma (LUAD) and squamous cell carcinoma (LUSC), PSAT1, SHMT1, SHMT2, MTHFD1 and MTHFD2 were significantly overexpressed compared to normal lung tissue (Fig. 1B). The gene discussed is SHMT1; the disease is non-small cell lung carcinoma.