In the mice model of chronic hepatitis with persistent infection of HBV preplasmid-induced recombinant cccDNA (rcccDNA), other researchers have discovered that activation of the STING signaling pathway can inhibit HBV replication by inhibiting ccc DNA-mediated transcription in hepatocytes and epigenetic modifications involved in HBV replication while also reducing liver tissue damage and fibrosis levels [32]. Here, STING1 is linked to chronic hepatitis.