To elucidate circHAS2’s specific functions in CRC, we established six experimental groups: control, circHAS2 oe, circHAS2 oe + miR-1244 mimics, circHAS2 oe + USP10 oe, circHAS2 oe + USP10 oe + miR-1244 mimics, and circHAS2 oe + CCNE2 sh in both cell lines. This evidence concerns the gene CCNE2 and colorectal carcinoma.