It has been previously shown experimentally that editing the risk variant rs13074711, which is associated with ER- BC, leads to altered expression of TNFSF10 and subsequent IFN-β-induced apoptosis, suggesting that the signal from TNFSF10 at the 3q26.21 locus may play a role in BC risk through immune defense mechanisms. This evidence concerns the gene IFNB1 and breast cancer.