In contrast, ER- genes were enriched for gene sets including numerous apoptosis pathways (caspase activation, Trail signaling, c-FLIP regulation) and other types of cancers (e.g., glioblastoma, non-glioblastoma glioma, esophageal cancer, leukemia) (Table S10 in Additional file 1). The gene discussed is CFLAR; the disease is glioma.