TNFSF10 and breast cancer: This finding suggests that SNPs in LD with the GWAS SNP rs10510097 may partially contribute to ER + BC etiology through altered expression of FGFR2. Another interesting gene we identified that uniquely associated with ER- BC was TNFSF10. This gene was first implicated in a GWAS of ER- BC in women with African ancestry [58]; later TNFSF10 was also implicated in a GWAS of overall breast cancer risk in women with European ancestry, but with a different risk variant [37].