The decreased expression level of pERK/pCREB after blocking BDNF-TrkB signaling suggests that the ERK/CREB pathway is critical for BDNF-TrkB signaling-mediated pain and aversion pain, and this ERK/CREB pathway may induce pain in FD/MAS by mediating oxidative stress and neuroinflammatory processes [42]. The gene discussed is CREB1; the disease is Fabry disease.