GDNF-GFRα1-Ret-ERK signaling has been reported to activate Runx2-mediated P3X1R gene transcription, which contributes to the sensitization of DRG neurons and induces bone pain; additionally, this study may provide a potential target mechanism leading to bone pain in FD/MAS patients. The gene discussed is GDNF; the disease is McCune-Albright syndrome.