The decreased expression level of pERK/pCREB after blocking BDNF-TrkB signaling suggests that the ERK/CREB pathway is critical for BDNF-TrkB signaling-mediated pain and aversion pain, and this ERK/CREB pathway may induce pain in FD/MAS by mediating oxidative stress and neuroinflammatory processes [42]. Here, NTRK2 is linked to Fabry disease.