Among these signaling effects, Piezo1-Akt signaling and the inhibition of sclerostin (which is an important regulator of bone formation), as well as its downregulation, affect osteoblast function in FD/MAS patients, and the activation of the Piezo1-Akt pathway in osteoblasts is needed for mechanical stretch-induced downregulation of sclerostin (Sost) expression. Here, AKT1 is linked to Fabry disease.