CD8A and neoplasm: In terms of intratumoral microorganisms, Talimogene laherparepvec (T-VEC) [a genetically modified type-I herpes simplex virus] can mediate the recruitment of CD8+ CTLs to the TME by modulating the secretion of type-I IFNs and chemokines (e.g., CXCL9 and CXCL10) and thereby triggering cytotoxic tumor-killing effects [154].