In addition, another study found that CXCR5+ICOS+CD8+ T cells show significant infiltration in tumor lymph nodes (LNs) of patients with Hodgkin’s lymphoma (HL) and could upregulate the expression of IL-2, IL-4, and IL-21 [123], which promotes B-cell proliferation and antibody production. This evidence concerns the gene IL4 and Hodgkins lymphoma.