Xu et al. found that anti-PD-1-IL-15m improves tumor-infiltrating T-cell function and antitumor immunity, and anti-PD-1-IL-15m enhances the proliferative capacity and cytotoxicity of CD8+ TILs and CD4+ TILs, but the underlying molecular mechanism has not been clarified [133]. This evidence concerns the gene CD8A and neoplasm.