In addition to its roles in mitotic control and the DDR pathway, MAD2L2 affects cancer development in various ways, such as regulating TCF4-induced cancer metastasis [36, 37], inhibiting colorectal cancer growth by promoting NCOA3 degradation [37], and recruiting PRDX2 to confer radioresistance in esophageal squamous cell carcinoma [38]. Here, TCF4 is linked to esophageal squamous cell carcinoma.