Multivariate analysis further demonstrated TET2/5hmC association (HR: 2.843; 95%CI: 1.226–3.605; P = 0.007), lymph node metastasis (HR: 5.241; 95%CI: 1.169–13.856; P = 0.037), and FIGO stage (HR: 3.979; 95%CI: 2.153–6.780; P = 0.023) were independent prognostic factors for EC patients (Table 3). This evidence concerns the gene TET2 and metastatic malignant neoplasm in the lymph nodes.