Thus, considering that higher levels of PKM2 expression correlate with an elevated activity of EGFR and inhibitor of NF‐kB kinase subunit beta (IKKβ)‐dependent pathways in human GBM cell lines, we decided to investigate iPA effects on the phosphorylation state of IKKβ‐NF‐kβ pathway in U87MG, U87MG‐EGFRwt, U87MG‐EGFRvIII and GBM4 primary cells. Here, EGFR is linked to glioblastoma.