Here we show for the first time that treatment of colorectal adenocarcinoma cells with postbiotics based on heat‐killed Lacticaseibacillus paracasei and Lactiplantibacillus plantarum attenuates SOCE via the modulation of Orai1 and STIM1 expression and inhibits the ability of these cells to migrate by impairing FAK tyrosine phosphorylation. The gene discussed is PTK2; the disease is colorectal adenocarcinoma.