We found that the levels of FAT10, P-AKT (Thr308) and P-S6 were significantly increased in both murine and human cells when compared with Celf2 WT + MA9 AML cells and CELF2 WT human MOLM-13 and K562 myeloid leukemia cells respectively, while the level of H3K79me was equivalent in Celf2 KO + MA9 and MA9 AML cells (Figs. 5E and S5B). This evidence concerns the gene AKT1 and acute myeloid leukemia.