Since FAT10 has been reported to directly promote cancer cell proliferation in various cancers by activating the AKT-mTORC1 signaling pathway [20], we examined the levels of FAT10, P-AKT (Thr308), P-S6 and H3K79me in Celf2 KO + MA9 AML mouse cells and CELF2 KD human MOLM-13 and K562 myeloid leukemia cells. Here, UBD is linked to acute myeloid leukemia.