TGFBI is known as the primary intracellular downstream signaling mediators of integrins and promotes αvβ5 integrin signaling to FAK (focal adhesion kinase), thereby contributing to cancer progression through its integrin-binding RGD motif in osteosarcoma, colon, and pancreatic cancer models12,14,15. This evidence concerns the gene TGFBI and familial pancreatic carcinoma.