MAPT and Alzheimer disease: Next, we investigated the association between CSF stages and insoluble Aβ aggregates (Aβ-PET), insoluble tau aggregates (tau-PET), neurodegeneration (cortical thickness and CSF neurofilament light (NfL)) and cognition, using a global cognitive composite sensitive to early AD changes (modified version of Preclinical Alzheimer’s Cognitive Composite (mPACC)35; Fig. 2).