Evidence for a potential role of EREG in cell proliferation comes from data on human brain tumors (Appendix Fig. S2) (Bao et al, 2014; Ceccarelli et al, 2016; Gill et al, 2014; Griesinger et al, 2013; Sun et al, 2014; Yan et al, 2012; Zhang et al, 2013). Here, EREG is linked to brain neoplasm.