We first dissected the spatial heterogeneity in an individual TNBC tumor and characterized 29 diverse cell states, including normal epithelial, cancer epithelial, immune cells (naive CD4+ T cells, effector memory CD4+ T cells, myeloid-derived suppressor cells (MDSCs), macrophages, CD8+ T cells) and stromal cells (endothelial, perivascular like (PVL), immature PVL). The gene discussed is CD4; the disease is neoplasm.