IGF1 and type 2 diabetes mellitus: A second example is the fine-mapped variant rs12454712 (chr18:63178651:T:C) for concentrations of circulating insulin-like growth factor 1 (IGF-1; PIP = 0.99) and type 2 diabetes (adjusted by BMI; PIP = 0.99) and lies in an intronic enhancer of BCL2(ref. 29).