Mechanistically, proinflammatory cytokines produced by Dnmt3a-deficient macrophages, including IL-20, enhanced osteoclastogenesis in mice, which demonstrated that CHIP progeny directly contributes to osteoporosis-inducing inflammation, osteoclast-mediated reduction in bone mass, and consequently endosteal niche deterioration [14]. Here, DNMT3A is linked to osteoporosis.