Proteins that are associated with MI, such as the atrial natriuretic peptide (NPPA, FC = 2.9274, FC = 8.9812, FC = 10.2193, p < 0.05, respectively at 1, 3, and 7d), monocyte differentiation antigen (CD14, FC = 2.8035, FC = 3.3507, FC = 4.30926965, p < 0.05, respectively at 1, 3, and 7d) and high mobility group protein B2(HMGB2, FC = 2.1010, FC = 2.3597, FC = 2.8397, p < 0.05, respectively at 1, 3 and 7d) were upregulated after MI in the heart tissue when compared with the Sham group (Fig. 4). Here, HMGB2 is linked to myocardial infarction.