Besides, PDE4A was related to heat shock protein B6 (HSPB6), aldehyde dehydrogenase 7A1 (ALDH7A1), A-kinase anchoring protein 1 (AKAP1), adrenoceptor beta 2 (ADRB2), SAG (an arrestin family member which desensitizes GPCR) and DISC1 (disrupted in Schizophrenia 1). The gene discussed is ADRB2; the disease is schizophrenia.