YEATS domain-containing proteins are identified as epigenetic readers, including four evolutionary conserved proteins in humans: Eleven-Nineteen Leukemia (ENL, encoded by YEATS1), YEATS2, ALL1-Fused gene from chromosome 9 protein (AF9, encoded by YEATS3), and Glioma Amplified Sequence 41 (GAS41, encoded by YEATS4). Here, MLLT3 is linked to leukemia.