GCLC and neoplasm: Moreover, by analyzing the survival data from the TCGA-LUAD dataset, the signature of high SLC7A11, high GCLC, and high YEATS4 expression predicted even worse overall survival than either parameter alone, suggesting that SLC7A11- and GCLC-mediated GSH synthesis and ferroptosis defense is responsible for GAS41-mediated tumor progression (Fig. 6k).