Despite the downregulation of genes related to TGF-β that were found in OM-dECM_DPSCs, both N- and OM-dECM_DPSCs significantly promoted calcium deposits of reseeded GSCs compared with N- and OM-dECM_GSCs in both growth medium and osteogenic medium condition, reflecting the functional property of dECM_DPSCs as the osteoinductive agent. The gene discussed is TGFB1; the disease is ocular melanoma.