TCF7 and non-small cell lung carcinoma: Furthermore, although the frequency of TIM3+PD1+CD8+ T cells was comparable in HGSOC and NSCLC samples (Fig. 3G), PD1+CD8+ T cells in NSCLC samples were preferentially polarized toward a TCF1+PD1+ T cell phenotype with effector functions (in both the TME as a whole and TLS areas) as compared to HGSOC samples (Fig. 3G–I).