On the other hand, our data linking the HGSOC (but not the NSCLC) environment to a predominance of ICI-insensitive TIM3+PD1+CD8+ T cells phenotype over (ICI-sensitive) TCF1+PD1+CD8+ T cells52,53,65–67 suggest that – at odds with NSCLC – the sparcity and limited maturation of TLSs in HGSOC fail to preserve an ICI-sensitive TCF1+PD1+CD8+ T cell compartment, rather allowing for the acquisition of a TIM3+PD1+ phenotype that has been associated with ICI resistance (Fig. 3). This evidence concerns the gene HAVCR2 and non-small cell lung carcinoma.