Confirming transcriptomic observations, we detected a higher density of CD8+ T cells, tumor core CD8+ T cells and GZMB+CD8+ T cells, as well as CD20+ B cells, DC-LAMP+ DCs, NKp46+ NK cells and CD3+FoxP3+ regulatory T (TREG) cells in samples from Cluster 3 patients as compared to Cluster 1 (Fig. 2E, F; Supplementary Fig. 4E). This evidence concerns the gene CD8A and neoplasm.