Finally, we aimed at comparing the abundance of lymphoid aggregates at different maturation stages and their T cell correlates in samples from patients with HGSOC vs NSCLC (Study cohort 5, Supplementary Table 6), as malignancy known to (1) have a high TMB, (2) respond to ICIs, especially when infiltrated by high amounts of TCF1+PD1+CD8+ T cells or when enriched for TLSs52–55 (Fig. 3E). This evidence concerns the gene CD8A and non-small cell lung carcinoma.