CD19 and neoplasm: As TLSs are known to contribute on development of tumor-targeting effector and memory T cell responses18,40, we next determined the impact of CD19+CD20+ B-cell depletion on the phenotypic and functional profile of tumor-infiltrating lymphocytes (TILs) isolated from freshly resected HGSOCs (n = 7; study cohort 6, Supplementary Table 7) and NSCLCs (n = 7; study cohort 7, Supplementary Table 8) with a high prevalence of TLSs (Fig. 4G; Supplementary Fig. 8A, B).