Similar to our findings in human tumor samples, TMBHi mouse ovarian tumors with high LAs frequency were associated with an increased density of effector T cells with a TCF1+PD1+CD8+, TIM3−PD1+CD8+ and TIM3+PD1+CD8+ T cell phenotypes as compared to their TMBLo counterparts (Fig. 6G). The gene discussed is HAVCR2; the disease is ovarian neoplasm.