Interestingly, three out of the four subtypes showing worse overall survival in MM patients (MAF: t(14;16), HRD low TP53: hyperdiploid with low TP53 expression and 1q gain: gain of chromosome 1q—further details in18) were found to be significantly enriched in NF-κB+ samples (Fig. 1b, Supplementary Fig. 1a). This evidence concerns the gene NFKB1 and Miyoshi myopathy.