To elucidate the link between the p52 cis-regulatory landscape and the activity of genes participating in oncogenic transcriptional programmes in MM, we profiled the H3K27ac and chromatin accessibility changes upon NFKB2 KD in KMS-11 cells and integrated it with patient epigenomic data (Fig. 3a–c and Supp. Here, NFKB2 is linked to Miyoshi myopathy.