Given the significant role of super-enhancers (SEs) in regulating myeloma transcriptomes and the ability of NF-κB to coordinate SE formation19,20,56, we analysed the SE profiles based on H3K27 acetylation in NFKB2 KD KMS-11 cells and primary MM tumours. This evidence concerns the gene NFKB2 and plasma cell myeloma.