NFKB1 and plasma cell myeloma: To further characterise the p52-dependent transcriptional programmes active in NF-κB+ multiple myeloma, we disrupted the constitutive expression of p52 in several NF-κB+ Multiple Myeloma cell lines (MMCL) by targeting the Rel Homology Domain (RHD; Fig. 1c) of the NFKB2 gene (NFKB2 KD).