We identified an association between the SR from cancer cells to CD8+ T cells and response with a small fold change for the shape parameter (|FCshape | = 0.11, FDRshape = 0.09), pointing to a difference in distribution that was not detected in terms of median 1-NN distances (Supplementary Figs. 7A-E, p = 0.98), suggesting that this may well be a false positive. The gene discussed is CD8A; the disease is cancer.