In locally advanced esophageal squamous cell carcinoma treated with chemoradiotherapy and SHR-1210 (anti-PD-1 ICI), a prognostic signal using the 1-NN statistic median reported PD-L1+ tumor cells closer to PD-L1- macrophages associated with a better OS after treatment25. Here, CD274 is linked to esophageal squamous cell carcinoma.