CD8A and cancer: In responding tumors, the distances from either CD8+ T cells or macrophages to the closest cancer cells were smaller than in non-responders (median 1-NN distance CD8+ T cell to cancer cell, responders = 4 ± 3μm, non-responders = 18 ± 15μm; Macrophage to cancer cell, responders = 4 ± 2μm, non-responders = 10.2 ± 7μm).