Both SRs showed the same direction of association with response in HNSCC (Fig. 5B) and, importantly, showed a statistically significant association with response after multiple testing correction: CD8+ T cells to cancer cells (FDRshape=0.045) and macrophages to cancer cells (FDRshape=0.0076, FDRscale = 0.00094) (Supplementary Fig. 11A, B), which matches with the spatial proximity behavior (lower 1-NN distances) identified in the responding UC tumors (Fig. 4E). This evidence concerns the gene CD8A and cancer.