The study also indicated that the optimal dose of trabedersen is 10 μM, as both its efficacy and safety tended to be superior to the 80 μM dose, although the mechanism for this counterintuitive result has not been fully understood.873 TGF-β1 antisense oligonucleotides or small interfering RNAs (siRNAs) were also developed and evaluated in different pre-clinical models, suggested as potential therapeutic strategies for tuberculosis,874,875 wound scarring,876,877 and several renal diseases.878–881. Here, TGFB1 is linked to kidney disorder.