Immunohistochemistry (IHC) staining on orthotopic tumor showed that EIF3H KD led to reduced levels of EIF3H, HAX1 and pERK1/2, and repressed cell proliferation (Ki67 staining), while HAX1 overexpression reversed these impacts caused by EIF3H KD (Fig. 5d). The gene discussed is HAX1; the disease is neoplasm.