HAX1 and neoplasm: To further investigate the functional contribution of dysregulated EIF3H/HAX1 axis to CRC tumorigenesis and metastasis, we established orthotopic CRC models by injecting Tet-on-inducible-shEIF3H HCT116 cells with or without ectopic expression of HAX1 into cecum to observe the tumor growth and metastasis (Fig. 5a).