In accordance with the hypoxic environment and increased acidosis observed in IBD [39, 121], low oxygen tension promotes the expression of pH-sensor OGR1 via HIF-1α in human monocytic cell lines, intestinal epithelial cells, and macrophages, suggesting a crucial role of OGR1 in hypoxia-associated responses [23]. The gene discussed is GPR68; the disease is inflammatory bowel disease.