The KEGG pathways were significantly associated with Natural killer cell mediated cytotoxicity, one carbon pool by folate, Glycerolipid metabolism, HIF-1 signaling pathway, Renal cell carcinoma, cGMP-PKG signaling pathway, Central carbon metabolism in cancer, Thyroid hormone signaling pathway, Tuberculosis, β-Alanine metabolism (Figure 6D). This evidence concerns the gene TG and hereditary clear cell renal cell carcinoma.