Finally, while anti-viral specificity of MX1 is largely determined by a disordered loop (L4) in the stalk domain [19], antiviral specificity of MX2 is determined by the N-terminal domain (NTD) [13,17], indicating that the mechanisms underlying inhibition of viral infection by MX1 and MX2 are distinct. The gene discussed is MX2; the disease is viral infectious disease.