Inhibition of HIV-1WT infection by chimeric MX1 expressing the N-terminal 91 amino acids of MX2 (MX1MX2-NTD) was reversed by CsA treatment in both HeLa and HT1080 cells (even enhancing HIV-1WT infection in CsA-treated HT1080 cells to a greater degree than MX2). Here, MX1 is linked to infection.