To shed light on the potential role of these mutations in TDP-43 pathogenesis, we have conducted energy calculations using two recently solved prototypical structures from patients with ALS-FTLD (PDB 7PY2) [27] Table 1 and Figure 5(b-f) or with type A FTLD-TDP (PDB 8CG3) [28] Table 1 and Figure 5(g-k). Here, TARDBP is linked to amyotrophic lateral sclerosis.