Based on these findings, it can be concluded that pyruvate functions in a cPLA2-dependent manner and that its mechanism of action is primarily dependent on the cPLA2-AA-NF-ĸB axis in attenuating meta-inflammation, obesity, and other obesity-mediated complications (Petersen et al., 2003). This evidence concerns the gene PLA2G4A and obesity due to melanocortin 4 receptor deficiency.