CHM may ameliorate patients’ fatigue symptom, with an average lower of 0.56 points in TCM fatigue syndrome scale (CHM vs. Drugs 0.38 scores lower; CHM plus drugs vs. Drugs 0.50 scores lower; CHM vs. no treatment 0.8 scores lower), and enhance body immunity, with an average increase of 5.26% in CD4 T lymphocytes percentage and lower of 14.64ng/L in serum IL-6 level. Here, CD4 is linked to Down syndrome.