NR1H4 and fatty liver disease: Higher levels of TβMCA are related to lower levels of FXR activity.91,92 It has been described that conventionally raised microbiome mice under a HFD feeding increase lipid accumulation in the liver due to higher expression in Cd36, ApoC2 and Vldlr genes when compared to germ-free (GF) mice.91 These data would suggest that, in part, gut microbiota can interact to FXR and partially induce hepatic steatosis.