Of note, genetic disruption of this metabolic cascade rendered macrophages resistant to AdsA-derived death-effector deoxyribonucleosides, leading to the accumulation of phagocytes within the deeper cavity of abscesses and accelerated clearance of staphylococci in vivo (Winstel et al., 2018; Winstel et al., 2019; Tantawy et al., 2022). Here, RNF170 is linked to abscess.