In contrast, RUT in large dose mitigated neuroinflammation by significantly reducing TNF-α and IL-1β levels, which is consistent with previous reports on RUT in neurodegenerative diseases including Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease (da Silva et al. 2017; Enogieru et al. 2018). The gene discussed is TNF; the disease is early-onset autosomal dominant Alzheimer disease.