In addition, to avoid disagreement, no subclonal TP53 mutations, which are thought to be one of the causes of discordances between p53 IHC expression [12] or TP53 mutations were included in the present study, given that, as mentioned above, assessment of tumor tissue with subclonal p53 expression was not targeted to areas with mutant pattern p53 staining. Here, TP53 is linked to neoplasm.