Similarly, the C-terminal portion of HIPK2 is required to recruit transcriptional corepressor CtBP and suppress β-catenin–mediated transcription necessary for regulation of mouse embryonic fibroblast proliferation (14) and associated with increased repression of YAP/TEAD-mediated gene transcription in cancer cell line, NSCLC (15). This evidence concerns the gene HIPK2 and cancer.