Regulation of protein acetylation itself is a complex process resulting from the net effect of acetyltransferases such as p300 — known to catalyze acetylation of MKP1 at Lys59 (47) — and deacetylases (SIRT proteins) whose actions are known to influence fibroblasts in IPF (75). Here, EP300 is linked to idiopathic pulmonary fibrosis.