A 6-protein marker combination of FCGR3B, FETUB, LRG1, ADA2, CD14, and SELL performed very well for both group comparisons: TB versus HCs with an AUC of 0.972 (95% CI: 0.937–1.000), sensitivity of 90.6% (95% CI: 73.8%–97.5%), specificity of 90.0% (95% CI: 72.3%–97.4%; Figure 11, A and B); and TB versus ORI with an AUC of 0.930 (95% CI: 0.867–0.993), sensitivity of 90.6% (95% CI: 66.5%–96.7%), and specificity of 80.8% (95% CI: 68.2%–94.5%) (Figure 11, C and D) at a probability cutoff of 0.5 or greater. The gene discussed is ADA2; the disease is tuberculosis.