Other autosomal dominant inherited syndromes associated to aggressive kidney cancers are hereditary Leiomyomatosis and Renal Cell Carcinoma (HLRCC) caused by loss of function of Fumarate Hydratase (FH), key enzyme of TCA cycle [8], Hereditary Papillary RCC (HPRC) which is linked to activating germline mutations in MET Proto-Oncogene tyrosine kinase receptor (MET) gene [9]. This evidence concerns the gene MET and hereditary leiomyomatosis and renal cell cancer.