In the most systematic study of its kind, here we characterized large-scale spatial associations between canonical cell types and brain tissue loss across cortical and subcortical GM areas in 13 neurodegenerative conditions (including EOAD, LOAD, PD, DLB, ALS, mutations in PS1, and clinical [bvFTD, nfvPPA, svPPA] and pathological [three-repeat and four-repeat tauopathies and TDPP43 proteinopathies types A and C] subtypes of FTLD). The gene discussed is PSEN1; the disease is amyotrophic lateral sclerosis.