Second, we describe the spatial associations of each healthy level of reference canonical cell types with atrophy in 13 low-to-high prevalent neurodegenerative conditions, including early- and late-onset AD, genetic mutations in presenilin-1 (PS1 or PSEN1), DLB, ALS, PD, and both clinical and pathological subtypes of frontotemporal lobar degeneration (FTLD). Here, PSEN1 is linked to Parkinson disease.