PSEN1 and amyotrophic lateral sclerosis: Pathological diagnosis confirmation was performed for EOAD and LOAD, DLB, PS1, FTLD-TDP types A and C, three-repeat tauopathy, and four-repeat tauopathy (Harper et al., 2017), while PD, ALS, and variants of FTD were diagnosed based on clinical and/or neuroimaging criteria (Parkinson Progression Marker Initiative, 2011; Kalra et al., 2020; Staffaroni et al., 2019), with some ALS patients being histologically confirmed postmortem (Kalra et al., 2020).